Every time you go to type an email address into iOS' Mail app, you get a giant list of everyone you've ever contacted that might fit the letters you've typed. This can get annoying very quickly. Here's how to delete those from your phone for good.
If you're using iOS 6, this is an easy tip for getting rid of those addresses. When you see one that you don't want saved in your recents, just tap the blue arrow next to it. From that new screen, you can just tap the big red "Remove From Recents" button to get rid of it completely. It's obvious once you think about it, yet I never thought to actually click on that blue arrow to see what was behind it.
Sadly, there's no way to mass delete recent addresses, you have to go one-by-one?but at least it's something. Hit the link to read more.
How to Delete Recent Recipients and Access Drafts Quickly on iOS Mail | Guiding Tech
It's tough to be a balloon over Antarctica. Most don't last more than a few weeks, but the Super-TIGER cosmic ray detector has been floating over the South Pole for 46 days and counting.
The Super-TIGER mission officially shattered the record for longest-running balloon-borne experiment in Antarctica on Jan. 19, scientists said. The project launched from the southernmost continent's Ross Ice Shelf on Dec. 9, and has already surpassed the previous record of 42 days, set by another cosmic ray detector, Cream I, which flew in the winter of 2004 to 2005.
"At 42 days of flight Super-TIGER is now the longest scientific balloon mission! We have over 50 million events!" mission scientists wrote on the project's Facebook page Jan. 19. "Records are made to be broken!"
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Before Super-TIGER's launch, experiment principal investigator W. Robert Binns, a physicist at Washington University in St. Louis, said "he would be deliriously happy if the balloon carrying the cosmic ray detector stayed up 30 days," according to a Washington University statement. [ Extreme Living: Scientists at the End of the Earth ]
Super-TIGER has circled the South Pole two and a half times, floating at a height of about 130,000 feet (40,000 meters), which is roughly three or four times higher than passenger jets fly.
From its high-up perch, the balloon-borne instrument can catch cosmic rays (charged particles from deep space) which are typically blocked from reaching the ground by Earth's atmosphere.
And lifting off from Antarctica is a boon, because the wind over the South Pole, called the polar vortex, tends to bring balloons back around in a circle to where they started, making them easy to retrieve after they've come back to the ground. Furthermore, the sun never sets during Antarctic summer, which helps balloons stay aloft.
"If you fly from northern Canada as we used to do, the helium in the balloon cools at night and the balloon starts to descend," Binns said in a statement. "The only way you can keep it up there is by dropping about 100 pounds of ballast. So because of the day/night cycle, flights are limited to about 40 hours, or two days. In Antarctica you can stay up much longer because you don?t have that problem."
But while Antarctica is perfect for balloons, it's less than ideal for humans. A day when the wind chill is above minus 75 degrees Fahrenheit (minus 59 degrees Celsius) is considered pleasant.
"Wednesday we had great weather here in McMurdo ? just about freezing," team member Ryan Murphy wrote Jan. 23 on his blog, Super-TIGER on the Ice.
However, the close-knit group of scientists who stay at McMurdo Station, the home base for U.S. research in Antarctica, find ways to amuse themselves. The scientists have regular Wednesday night soccer games, Murphy wrote, and the Super-TIGER team even worked with researchers back at Washington University to photograph a "trophy" to commemorate their record-setting flight.
"Through the Photoshop skills of the team back at Wash U, we now have a picture of an awesome real-looking trophy for the longest Antarctic balloon flight," Murphy wrote of a bowling trophy made to look like an official NASA commemoration of Super-TIGER's achievement. "This trophy does not exist. But I kind of wish it did."
Super-TIGER isn't the only balloon-borne experiment launched this season from the South Pole. The Balloon-borne Large-Aperture Submillimeter Telescope (BLAST) experiment launched Dec. 25 to study star formation in the Milky Way, while the EBEX telescope took flight on Dec. 19 to survey the cosmic microwave background radiation left over from the Big Bang.
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FILE - In this Aug. 26, 2010 file photo, Navy Secretary Ray Mabus is interviewed by The Associated Press at the Pentagon in Washington. The Navy on Wednesday, Jan. 23, 2013 said it will conduct random blood-alcohol tests on its sailors in the United States starting next month, a sign of how concerned the service's leaders have become about the effects alcohol abuse is having on the force. The tests are part of Mabus' 21st Century Sailor and Marine Initiative, an expansive program intended to improve the well-being of sailors and Marines after more than a decade at war. (AP Photo/Charles Dharapak, File)
FILE - In this Aug. 26, 2010 file photo, Navy Secretary Ray Mabus is interviewed by The Associated Press at the Pentagon in Washington. The Navy on Wednesday, Jan. 23, 2013 said it will conduct random blood-alcohol tests on its sailors in the United States starting next month, a sign of how concerned the service's leaders have become about the effects alcohol abuse is having on the force. The tests are part of Mabus' 21st Century Sailor and Marine Initiative, an expansive program intended to improve the well-being of sailors and Marines after more than a decade at war. (AP Photo/Charles Dharapak, File)
NORFOLK, Va. (AP) ? The Navy said Wednesday it will conduct random blood-alcohol tests on its sailors in the United States starting next month, a sign of how concerned the service's leaders have become about the effects alcohol abuse is having on the force.
The tests are part of Navy Secretary Ray Mabus' 21st Century Sailor and Marine Initiative, an expansive program intended to improve the well-being of sailors and Marines after more than a decade at war.
The Marines announced it would carry out its own random alcohol tests last month. While alcohol has long played a part in the Navy's culture, Navy officials stressed they aren't trying to stop sailors from drinking altogether, but are concerned about their health and safety.
The Navy said it will use the blood-alcohol tests to determine whether someone is fit for duty or may need counseling. Any sailor whose blood-alcohol level is .04 or higher when reporting for duty won't be allowed to work. In all 50 states and the District of Columbia, a driver with a 0.08 percent blood-alcohol is considered drunk.
A positive test result for a sailor reporting to work ? a reading of 0.02 percent or higher ? won't be used to punish sailors. But the Navy said it could be used to refer him or her to a drug and alcohol program adviser.
Adm. Mark Ferguson, vice chief of naval operations, said the random tests could help spot sailors who need support before "an incident occurs due to the irresponsible use of alcohol." He also wrote in a message outlining the new details of the policy to the fleet that the tests will serve as a safety measure and raise awareness among commanding officers of a crew's "culture of alcohol use."
Alcohol is of particular concern because of the role it frequently plays in other destructive behaviors such as suicide and sexual assault. Alcohol also has played a factor in the dismissals of a number of commanding officers in recent years.
"Deterring irresponsible use of alcohol is essential to the readiness of our fleet and ensuring the health and safety of our service members and units," Adm. Bill Gortney, commander of U.S. Fleet Forces, said in a statement.
In a pilot program with 13 commands this past summer, nearly 7,500 sailors were subjected to random alcohol tests. Of those, 87 tested positive for alcohol.
"The test verified that the majority of our service members, who choose to drink alcohol, do so responsibly. It also verified that our commanding officers need a flexible program that serves to increase the Navy's awareness about the impacts of alcohol," Gortney said in a statement.
By May 24, the Navy expects to have hand-held alcohol detection devices available for nearly 2,000 commands.
The 21st Century Sailor and Marine Initiative was unveiled by Mabus in a rare 'all-hands' call aboard a ship in Norfolk last March that was broadcast to sailors around the world. Among other things, it also focuses on preventing suicides, sexual assaults and increasing physical fitness. The Navy has also begun conducting random urine tests for synthetic drug use under the initiative.
Unlike the alcohol tests, those who test positive for synthetic drug use are subject to punishment.
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Brock Vergakis can be reached at www.twitter.com/BrockVergakis
Jan. 22, 2013 ? An article from John Appleby, Chief Economist at the Kings Fund, published on bmj.com today brings attention to the rising amount of those expected to live to 100 and asks where it will end.
According to the Office of National Statistics there seems to be "no end in sight" as far as the number of UK citizens reaching 100 years old is concerned. Approximately 13% of girls born in 1951 are expected to reach this milestone, increasing to 40% for girls born this year and a predicted 60% of those born in 2060.
Appleby attributes similar worldwide trends to the fact that people are dying at older ages. Deaths in children under five have fallen by 60% since 1970, and surviving early childhood makes it easier to live a much longer life.
Variations between men and women, social groups and countries have, however, remained significant with one UK study finding a difference of 11.4 years (80 years compared with 68.6 years) between women in the poorest and most affluent social classes.
And although "living longer is a good thing," research suggests that gains in life expectancy have more to do with reductions in deaths than reductions in years lived in disability. While life expectancy for women has risen 4.6% since 1990, healthy life expectancy has risen by only 3%.
As more and more people live longer, Appleby asks whether we may find ourselves "scrabbling for resources" but concludes that this is unlikely and there is "no need to panic."
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The above story is reprinted from materials provided by BMJ-British Medical Journal.
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Journal Reference:
J. Appleby. How long can we expect to live?BMJ, 2013; 346 (jan22 3): f331 DOI: 10.1136/bmj.f331
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
If you're one of the many still trying to get your hands on a Nexus 4, and happen to live in Australia, we have some good news. Starting February 1, the phone that plays hard to get will be available in retail stores across the land of Oz. The 16GB version will set you back $499 AUD (that's about $525 US) without any pesky contracts or commitments. Of course, you can also choose to get it bundled with an Optus plan for just $35 AUD (about $37 USD) a month.
The pricing isn't bad compared to retail on other unlocked phones, but is still marked up a bit over the Google Play price of $349 US. It's a case of demand setting the market price, and it's still cheaper than eBay.
JOHANNESBURG (Reuters) - South Africa will likely miss its target of creating five million jobs by 2020, given labour strife and strained relations between the government and private firms, a newspaper quoted a deputy minister as saying.
"We are not going to achieve them (job targets) if we don't systematically look at priority sectors," Economic Development Deputy Minister Hlengiwe Mkhize told Business Day in an interview - marking the first such public admission by a government minister.
President Jacob Zuma's government has pushed a major development plan to slash unemployment to 15 percent from 25 percent over seven years, but economic growth remains far below the levels needed to reduce the problem, carving deep social divisions in Africa's largest economy.
Referring to one priority sector, Mkhize said often-violent wildcat strikes in recent months and the threat of job losses at some of the country's mines stand in the way of creating jobs.
Two major mining firms are looking to slash jobs due to labour strife with Anglo American Platinum, the largest producer of the precious metal, planning to mothball some of its operations and cut some 14,000 jobs.
Harmony Gold, South Africa's third-largest gold producer also plans to mothball its Kusasalethu mine, which could lead to 6,000 job losses.
Zuma's ruling African National Congress has severely criticised the moves and threatened to review mining licenses.
The possibility of further job losses has kept tensions simmering in the mining sector after strikes last year left more than 50 people dead and shaved off about 0.5 percentage points from the country's 2012 economic growth.
The Treasury has forecast growth of 3 percent this year from 2.5 percent in 2012, far below the 7 percent the country needs to significantly reduce the jobless rate.
The voting is over and the results are in. So, Psychsoftpc, the high performance gaming computer manufacturer, announces its first annual PC Game of the Year Award Winner. This year's nominees were:
Mass Effect 3
COD Black Ops 2
Assassin's Creed 3
FAR CRY 3
Borderlands 2
Diablo III
Dishonored
Hitman: Absolution
Max Payne 3
Sleeping Dogs
The Witcher 2
Walking Dead
The winner, determined by fan votes, is...Dishonored! Runner up is...Mass Effect 3! Congratulations to both games.
All nominees garnered industry acclaim and large fan base support. Fans are passionate about their games and the voting showed. This award is solely for games that support gaming on the PC. Gaming on the PC is a viable and growing segment of the gaming market and this Game of the Year Award is in recognition of that.
To see the voting results for 2012, fans should go to:
WASHINGTON (AP) ? Three U.S. citizens were killed in last week's hostage standoff at a natural gas complex in Algeria, while seven Americans made it out safely, Obama administration officials said Monday.
The State Department confirmed that gas workers Victor Lynn Lovelady and Gordon Lee Rowan were killed at the Ain Amenas field in the Sahara. U.S. officials identified Texas resident Frederick Buttaccio as the first death last week.
"I'm glad we were able to get some rescued, but we did lose three Americans," Defense Secretary Leon Panetta said as he was leaving the Capitol, where he attended President Barack Obama's second inauguration. "That just tells us that al-Qaida is committed to creating terror wherever they are and we've got to fight back."
A U.S. official had told The Associated Press earlier Monday that the FBI had recovered Lovelady's and Rowan's bodies and notified their families. The official had no details on how the Americans died, and their hometowns were not released.
Militants who attacked Ain Amenas had offered to release Lovelady and Rowan in exchange for the freedom of two prominent terror suspects jailed in the United States: Omar Abdel Rahman, a blind sheik convicted of plotting to blow up New York City landmarks and considered the spiritual leader of the 1993 World Trade Center bombing, and Aafia Siddiqui, a Pakistani scientist convicted of shooting at two U.S. soldiers in Afghanistan.
The Obama administration rejected the offer outright.
State Department spokeswoman Victoria Nuland said the U.S. was still working with Algeria's government to gain a fuller understanding of the attack and to enhance their counterterrorism cooperation in future.
"We extend our deepest condolences to their families and friends," she said in a statement. "The blame for this tragedy rests with the terrorists who carried it out, and the United States condemns their actions in the strongest possible terms."
Last week's desert siege began Wednesday when Mali-based, al-Qaida-linked militants attempted to hijack two buses at the plant, were repelled, and then seized the gas refinery. They said the attack was retaliation for France's recent military intervention against Islamist rebels in neighboring Mali, but the captured militants told Algerian officials it took two months to plan.
Five Americans had been taken out of the country before Saturday's final assault by Algerian forces against the militants.
The U.S. official said the remaining two Americans survived the four-day crisis at an insecure oil rig at the facility. They were flown out to London on Saturday.
The State Department's Nuland confirmed that seven Americans made it out safely, but said she couldn't provide further details because of privacy considerations.
Algeria says 38 hostages of all nationalities and 29 militants died in the standoff. Five foreign workers remain unaccounted for.
Lovelady, 57, worked at Ain Amenas as a project manager for the Houston-based energy firm ENGlobal Corporation, said CEO William A. Coskey. Rowan's employer wasn't immediately known.
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Associated Press writer Donna Cassata contributed to this report.
Plan your client's summer escape now and soon enough they will be relishing the stunning views of the Amalfi Coast, French Riviera and Costa del Sol from the plush comfort of a private verandah aboard the award-winning Crystal Symphony. On six Mediterranean journeys ranging from 7- to 12-days?including two with Saturday departures?your clients will find themselves exploring ancient ruins in Rome, Ottoman treasures in Istanbul, and iconic beaches in Mykonos. Experience the all-inclusive luxury of Crystal with Book Now Savings of up to $1,200 per person when you book your client's cruise by February 28, 2013 with fares from just $2,495!
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"A new study shows that video games provide elation much like a drug can. There is so much euphoria and endorphin rush that comes with SOME games that people can become addicted to them. In essence, they get a high. However, like with some drugs, once they are not gaming, their mood and endorphin levels are such that they are more depressed and are less sociable as they WOULD BE if they were not playing the games in a habitual-addictive like manner.
What better time to announce a smartphone than in the lull between CES and MWC? Micromax is using the occasion to reveal another five-inch handset, the Canvas HD. The display packs a 1,280 x 720 resolution, and inside you'll find a MediaTek MT6589 1.2 GHz quad-core processor and a 2100mAh battery. The phone's also got an 8-megapixel rear camera and expandable storage up to 32GB. All of that's powered by Android 4.1. The Canvas HD is coming to India the first week of February, carrying a Rs. 15,000 ($279) price tag. Assorted additional information can be found in the press release after the break.
Show full PR text
Micromax launches Canvas HD to strengthen phablet leadership
Micromax, India's leading handset manufacture today announced its partnership with MediaTek, the leading chipset manufacturers for the launch of their first quad core processor phone -A116 Canvas HD.
Designed for comfort and convenience, the Canvas HD is powered by MediaTek's MT6589 1.2 GHz quad core processor and run on Android Jelly Bean. With an HD IPS screen with a HD resolution of 1280x720 and a color depth of 16.7 million, the phone comes with superb graphics and HD viewing experience. Supported by a 2100mAh battery, it is the ideal phone for the young generation who is always on the lookout for better, faster and savvier smart phones on the go!
Commenting on the launch and association with MediaTek, Mr. Deepak Mehrotra, Chief Executive Officer, Micromax said, "At Micromax, we constantly strive to innovate and develop great technological experiences for our consumers. Today's launch marks our association with MediaTek to bring forth our first quad core phone in this segment, offering consumers a great user experience with latest features and added functionality." He further added, "We are excited with the success of Canvas 2, which has clearly established Micromax as number one player in the new 5" phablet category in India. We are looking forward to similar success with the new phone being unveiled today."
The A116 Canvas HD promises superior quality graphics, multi-tasking and improved application performance. The phone sports an 8MP rear camera with LED flash and multiple camera settings such as night mode, 4X zoom - to further enhance the superiority of the memorable moments. 3G enabled A116 will help users in faster browsing, downloading attachments and watching streaming videos with excellent quality. The users can download HD quality videos and watch them on their phone without compromising with the quality. Users now can get to keep all their downloaded music by storing them in the phone's external memory which is expandable up to 32GB.
Speaking at the occasion, Dr. Finbarr Moynihan, General Manager - Business Development at MediaTek, said, "In less than 2 years of launching our first smartphone chipset, MediaTek's shipments in this category have grown more than ten times, with 110 million units in 2012. As the world's first commercialized quad-core Cortex-A7 SoC, the MT6589 is an innovative solution that accelerates product development, simplifies differentiation, and offers the best possible experience that mid to high-end smart device owners desire. Micromax shares our core philosophy of pushing the bar on innovation and bringing it within the reach of the masses. We are delighted that India's leading youth mobile brand has chosen MediaTek to power its top-end mobile smartphones."
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Article marketing has many benefits which may include establishing yourself as an Author, lead generation, more traffic to your web site, improved search engine position and is becoming a necessary tool for doing business on the World Wide Web.? Article marketing has become a proven strategy for raising your link popularity.? It can also be a cheap way to compete with larger companies in your field.
It's best to write on topics that are closely related to your business type, while making sure that the article provides good content for the reader, no one wants to read a sales page.? Every article that you write will need a resource box section that will contain your sales info including an (anchor text) link or two pointing to your Web site.? You could have a terrific product and a wonderful sales strategy, but without the targeted traffic your online business could be going no-where.
No More Excuses: Article Marketing is Free and Easy to Do.
You can take advantage of a ton of free article submissionsites on the internet, where you can submit your articles for free, some also offer software and services to help in the process.? Once approved, the sites will make your articles available for distribution and publication to ezines, webmasters etc...? Now there is no more need to beg for reciprocal link exchanges, pay for text links, or spend hours posting free ads to link farms that no one will read anyway.? Articles, written yourself, are becoming the fastest and cheapest way to see results from your efforts.
When done properly, article marketing can be a very powerful tool to drive loads of targeted traffic to your web site.? Whether your business is brand new or you have been in business for a while, you can gain new customers from marketing your own articles.? To be the most effective, article marketing should just be part of a larger, more comprehensive SEO strategy.? Remember, the goal of successful marketing is increased business and most importantly profit and this can be achieved with the help of article marketing.
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CONCORD, N.H. (AP) ? An avalanche has halted an attempt by a retired Marine and amputee to climb the Northeast's highest peak, but if his past comments are any indication, he'll likely try again.
Retired Sgt. Keith Zeier was in the hospital Friday, a day after he and two fellow climbers were injured in an avalanche on Mount Washington. The climb was part of a project called "Ascents of Honor" and was the latest of several grueling challenges the 26-year-old has taken on to raise awareness and money for the families of special operations forces killed or wounded in action.
"In the middle of anything that is difficult, we have the option of quitting, slowing down, or changing course. My life has been about ignoring that option," Zeier wrote last month on the Ascents of Honor blog.
According to an update on the group's Facebook page, Zeier was part of a 12-member crew trying to reach the 6,288-foot summit Thursday evening when a slab avalanche brook loose and swept three climbers to the bottom of Huntington Ravine. Zeier and the other injured climbers were able to slowly make their way to rescuers who assisted them off the mountain, the group said.
"While this is certainly not the outcome we had hoped for, we are thankful that all in our party are safely off the mountain," wrote Thom Pollard, the project's head cameraman.
One of the injured climbers, J.P. Politz, was released from the hospital Friday. His father, Andy Politz, also was injured; his condition was not available. Zeier's mother said Friday morning she had not yet spoken to her son but his doctors said his prognosis was promising, and a nurse told her he was resting comfortably in stable condition.
Denise Zeier said the episode brought back memories of her son's injuries in Iraq in 2006. When she heard there had been an avalanche, "I knew. I just knew it was going to be him," she said.
Before his leg was amputated several years ago, Zeier ran several marathons to raise money for the Special Operations Warrior Foundation, his mother said. Last summer, he climbed Washington's Mount Rainier and was looking forward to Thursday's climb, she said.
"He has a good heart. He'd give you the shirt off his back, and he gets very passionate about things he believes in," she said. "He has no fear. He was in special ops himself, so he has a lot of skills."
Tiffany Benna, public affairs officer for the U.S. Forest Service in New Hampshire, said there was a "moderate avalanche advisory" in effect for Huntington Ravine on Thursday, meaning the likelihood of a naturally-occurring avalanche was nil but a human-triggered avalanche was possible.
The forest service received the first call about the avalanche at about 5:30 p.m. The agency's first ranger arrived by 6:45 p.m. and the injured climbers were loaded into ambulances by 9:30 p.m. Also participating in the rescue were members of the North Conway Mountain Rescue Service, the Appalachian Mountain Club and the Harvard Mountain Club cabin caretaker.
Asked whether the climbers should have been scaling the mountain after darkness, Benna said it would depend on their level of expertise and the gear they carried.
"If you're prepared to be in that type of weather and in darkness, it's a hard thing to say 'should' or 'shouldn't have,'" Benna said. "I don't know how they were outfitted ? if they had headlamps and gear to do a nighttime trip."
According to the Ascents of Honor website, the group was keenly focused on safety and had assigned one climber to oversee safety decisions ranging from gear choice to navigation. The group plans to produce a film that would inspire viewers to contribute to the Special Operations Warrior Foundation and do whatever they can to help veterans in their communities.
Mount Washington is known for its brutal weather conditions. For decades, it held the distinction as the site of the fastest wind gust ever recorded on Earth, but the 231 mph record set in 1934 was topped by a 253 mph gust on an Australian island in 1996.
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Associated Press writer Lynne Tuohy contributed to this report.
Cell: Protein folding via charge zippersPublic release date: 18-Jan-2013 [ | E-mail | Share ]
Contact: Monika Landgraf presse@kit.edu 49-721-608-47414 Helmholtz Association of German Research Centres
This press release is available in German.
Membrane proteins are the "molecular machines" in biological cell envelopes. They control diverse processes, such as the transport of molecules across the lipid membrane, signal transduction, and photosynthesis. Their shape, i.e. folding of the molecules, plays a decisive role in the formation of, e.g., pores in the cell membrane. In the Cell magazine, researchers of Karlsruhe Institute of Technology and the University of Cagliari are now reporting a novel charge zipper principle used by proteins to form functional units (DOI: 10.1016/j.cell.2012.12.017).
"It is fascinating to see the elegant basic principles that are used by nature to construct molecular assemblies," explains Anne Ulrich, Director of the KIT Institute for Biological Interfaces. "A charge zipper between the charged side chains is an entirely unexpected mechanism used by membrane proteins to neutralize their charges such that they can be immersed into hydrophobic cell membranes."
In the study published now, Ulrich and her team investigate the so-called Twin-arginine translocase (Tat) that is used in the cell membrane of bacteria as an export machinery for folded proteins. Several TatA subunits assemble as a pore that can adapt its diameter to the size of the cargo to be transported. "But how can such a pore be built up from TatA proteins? How can they reversibly form a huge hole in the membrane for a variety of molecules to pass through, but without causing leakage of the cell?", Ulrich formulates the questions studied.
To answer these questions, the researchers studied the molecular structure of TatA protein from the bacterium B. subtilis, which consists of a chain of 70 amino acids. The analysis showed that it folds into a rather rigid, rod-shaped helix that is followed by a flexible, extended stretch. Many amino acids in the helix and the adjacent stretch carry positive or negative charges. Surprisingly, the sequence of charges on the helix is complementary to those in the adjacent stretch of the protein. When the protein is folded up at the connection point like a pocket knife, positive and negative charges will always meet and attract each other. Hence, the protein links up both of its segments, similar to the interlocking teeth of a zipper.
"The clou is that this binding principle also works with the neighboring proteins," Ulrich says. Instead of folding up alone, every TatA protein also forms charge zippers with both of its neighbors. Computer simulations showed that this leads to stable and, at the same time, flexible connections between the adjacent molecules. In this way, any number of proteins can be linked together to form an uncharged ring, which thus lines the TatA pore in the hydrophobic membrane. This novel charge zipper principle does not only seem to play a role in protein transport, but also in the attack of certain antimicrobial peptides on bacteria, or in their formation of biofilms as a response to stress.
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More information on the working group: http://www.ibg.kit.edu/nmr/.
Karlsruhe Institute of Technology (KIT) is a public corporation according to the legislation of the state of Baden-Wrttemberg. It fulfills the mission of a university and the mission of a national research center of the Helmholtz Association. KIT focuses on a knowledge triangle that links the tasks of research, teaching, and innovation.
This press release is available on the internet at www.kit.edu.
The photo of printing quality may be downloaded under www.kit.edu or requested by email or phone. The photo may be used in the context given above exclusively.
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Cell: Protein folding via charge zippersPublic release date: 18-Jan-2013 [ | E-mail | Share ]
Contact: Monika Landgraf presse@kit.edu 49-721-608-47414 Helmholtz Association of German Research Centres
This press release is available in German.
Membrane proteins are the "molecular machines" in biological cell envelopes. They control diverse processes, such as the transport of molecules across the lipid membrane, signal transduction, and photosynthesis. Their shape, i.e. folding of the molecules, plays a decisive role in the formation of, e.g., pores in the cell membrane. In the Cell magazine, researchers of Karlsruhe Institute of Technology and the University of Cagliari are now reporting a novel charge zipper principle used by proteins to form functional units (DOI: 10.1016/j.cell.2012.12.017).
"It is fascinating to see the elegant basic principles that are used by nature to construct molecular assemblies," explains Anne Ulrich, Director of the KIT Institute for Biological Interfaces. "A charge zipper between the charged side chains is an entirely unexpected mechanism used by membrane proteins to neutralize their charges such that they can be immersed into hydrophobic cell membranes."
In the study published now, Ulrich and her team investigate the so-called Twin-arginine translocase (Tat) that is used in the cell membrane of bacteria as an export machinery for folded proteins. Several TatA subunits assemble as a pore that can adapt its diameter to the size of the cargo to be transported. "But how can such a pore be built up from TatA proteins? How can they reversibly form a huge hole in the membrane for a variety of molecules to pass through, but without causing leakage of the cell?", Ulrich formulates the questions studied.
To answer these questions, the researchers studied the molecular structure of TatA protein from the bacterium B. subtilis, which consists of a chain of 70 amino acids. The analysis showed that it folds into a rather rigid, rod-shaped helix that is followed by a flexible, extended stretch. Many amino acids in the helix and the adjacent stretch carry positive or negative charges. Surprisingly, the sequence of charges on the helix is complementary to those in the adjacent stretch of the protein. When the protein is folded up at the connection point like a pocket knife, positive and negative charges will always meet and attract each other. Hence, the protein links up both of its segments, similar to the interlocking teeth of a zipper.
"The clou is that this binding principle also works with the neighboring proteins," Ulrich says. Instead of folding up alone, every TatA protein also forms charge zippers with both of its neighbors. Computer simulations showed that this leads to stable and, at the same time, flexible connections between the adjacent molecules. In this way, any number of proteins can be linked together to form an uncharged ring, which thus lines the TatA pore in the hydrophobic membrane. This novel charge zipper principle does not only seem to play a role in protein transport, but also in the attack of certain antimicrobial peptides on bacteria, or in their formation of biofilms as a response to stress.
###
More information on the working group: http://www.ibg.kit.edu/nmr/.
Karlsruhe Institute of Technology (KIT) is a public corporation according to the legislation of the state of Baden-Wrttemberg. It fulfills the mission of a university and the mission of a national research center of the Helmholtz Association. KIT focuses on a knowledge triangle that links the tasks of research, teaching, and innovation.
This press release is available on the internet at www.kit.edu.
The photo of printing quality may be downloaded under www.kit.edu or requested by email or phone. The photo may be used in the context given above exclusively.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Posted by admin on Jan 17, 2013 in Home Improvement | 0 comments
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Just days before he again takes the oath of office, President Barack Obama is rounding out his Cabinet and White House staff while bracing for major economic and foreign policy storms.
Just when one crisis seems resolved or put off, another one springs up.
The latest emergency: the capture by Islamic militants of dozens of foreign hostages, including some Americans, at a natural gas complex in the Algerian desert. Algerian forces raided the plant on Thursday in an attempt to free the hostages, but heavy casualties were reported among both hostages and militants.
At home, Obama has already picked nominees for his national security and economic teams, including the top jobs at the State Department, the Pentagon, CIA and Treasury Department.
Now he appears poised to name Denis McDonough, a senior national security aide, to be his fifth chief of staff. McDonough would replace Jack Lew, nominated by Obama to be treasury secretary.
McDonough brings rare foreign policy experience to the influential White House post .
He helped shape the White House response to winding down the wars in Iraq and Afghanistan, confronting Iran over its nuclear program and reacting to the Arab spring uprisings.
As chief of staff, he could also weigh in quickly on overseas challenges.
Some big tests of will for Obama can be seen coming, such as a series of fiscal deadlines due to hit in February and March over the debt limit and automatic spending cuts.
But others crop up suddenly, such as the hostage-taking in Algeria ? by militants with ties to rebel Islamists fighting government and French forces in bordering Mali.
The chief of staff post does not require Senate confirmation.
Obama is sworn in for a second term on Sunday, with public Inauguration Day ceremonies to be held on Monday.
Meanwhile, Speaker John Boehner and other House Republicans are attending an annual winter retreat near colonial Williamsburg, Va., to reunite and regroup for the coming battles with the re-elected Democratic president.
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Follow Tom Raum on Twitter: http://www.twitter.com/tomraum
ATLANTA, GA--(Marketwire - Jan 17, 2013) - Hardin Construction Company's latest project at Young Harris College -- a student-residence complex configured in small communities called "pods" -- is contributing to a campus-building program that's as breathtaking as the views from the college's mountainous North Georgia campus.
Hardin has begun construction on a facility that will provide 200 beds for first-year students in time for Fall 2013 occupancy. The complex is being constructed to LEED standards and is targeting LEED certification.
Consistent with a growing residence life trend nationally of colleges providing living and learning spaces that foster student interaction, the 62,000-square-foot, pod-style complex will consist of three adjoining pavilions -- two 4-story buildings and a 3-story building -- offering rooms of different sizes and styles surrounding a common bath area and featuring study and social spaces.
The project's architect of record is Lord, Aeck & Sargent, Inc.
The new student housing is Hardin Construction's fourth LEED-certified or LEED-targeted project at Young Harris College. All are part of the liberal arts college's transformation from a two-year college to a comprehensive four-year institution with state-of-the-art facilities to support growing enrollment and program offerings.
Hardin Construction's other recent LEED projects at Young Harris include The Village, a 248-bed, apartment-suites community for upperclassmen that is pursuing LEED certification; the 200-bed, LEED Silver Enotah Hall residence hall; and the college's 57,000-square-foot Recreation and Fitness Center, which earned LEED Certified status.
About Hardin Construction Celebrating 66 years of excellence, Hardin Construction Company, LLC is one of the nation's leading construction services firms, providing unequalled expertise for projects of broad scope and complexity through its culture of integrity, innovation and opportunity. With capabilities in general construction, construction management, design-build and renovation, Hardin is a leader in green building and sustainable practices and is recognized nationally for its safety practices. Privately-held, Hardin's headquarters is in Atlanta, Ga., with branch offices in Atlanta, Tampa, Fla., Orlando, Fla., Raleigh, N.C., and Austin, Texas. For more information, visit www.hardinconstruction.com.
Documents and/or Photos available for this release: Hardin Young Harris College Freshman Pods
To view supporting documents and/or photos, go to www.enr-corp.com/pressroom and enter Release ID: 345112
Every time you go to type an email address into iOS' Mail app, you get a giant list of everyone you've ever contacted that might fit the letters you've typed. This can get annoying very quickly. Here's how to delete those from your phone for good. 
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Public release date: 18-Jan-2013
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Posted by admin on Jan 17, 2013 in Home Improvement | 0 comments 